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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and also reduces bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They also provide a useful method of determining the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for explanatory studies.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study which includes recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. 프라그마틱 무료스핀 suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.