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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also helps reduce bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. 프라그마틱 슬롯 추천 are usually commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causality of an intervention and its results. However, they should not, be used to replace explanation studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a practical trial that include recruitment, design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.